"First Love" is a comedy-drama, set in one of Miike's favourite environments, the world of the Yakuza (Gangster). A promising boxer, Leo (Masataka Kubota), is surprisingly beaten in a contest and is informed it is probably due to an inoperable brain tumour. Whilst walking the streets attempting to process this news, he bumps into drug-addicted sex slave Yuri (Sakurako Konichi) and inadvertently messes up an attempt by a crooked cop and an up-and-coming Yakuza to steal a drug shipment from the local crime family. Along the way, we meet One-armed Chinese crime bosses, deadly female assassins, and murderously unhinged girlfriends, amongst other characters too numerous to list. Somehow, amongst the violence and craziness, the two form a connection with each other, but only if they survive.